A method combining decomposition strategy with niche clonal selection algorithm for multi-UAV cooperation path planning problem is put forward. While constraining the UAV to arrive at the target simultaneously, the decomposition strategy is proposed, and the niche clonal selection algorithm can search multiple feasible paths for each UAV. The application of the coordination variable and coordination function approach is applied to multi-UAV cooperation path planning problem. The simulation results show that the method can solve multi-UAV cooperation path planning problem effectively.